會議議程

Executive Summary：
Dr. Chin-Wei Huang is Director and Professor of Neurology at National Cheng Kung University (NCKU) in Taiwan, where he also leads the Epileptology Division. He received his MD from Kaohsiung Medical University and his PhD from NCKU, followed by advanced training in Japan and Canada. A board-certified neurologist and neurocritical care specialist, he also holds EEG certification from the Canadian Society of Clinical Neurophysiologists.
Dr. Huang’s research centers on epileptogenesis, translational neuroscience and clinical epileptology, with over one hundred peer-reviewed publications and multiple awards from national and international societies. He previously served as President of the Taiwan Epilepsy Society and is currently a member of the Medical Therapies Task Force of the International League Against Epilepsy (ILAE). In addition to his research and leadership roles, he is actively engaged in education, leading EEG and epilepsy teaching programs across Asia and mentoring the next generation of epilepsy specialists.

Lecture Abstract：
Epilepsy is increasingly recognized as a complex network disorder in which seizures represent only one dimension of broader disturbances involving metabolism, systemic comorbidities, and neuronal excitability. Conventional seizure-focused approaches often overlook the biological heterogeneity and long-term disease trajectories that influence outcomes in patients with epilepsy.
Our research has explored epileptogenesis across clinical, translational, and population-based frameworks. We have demonstrated that comorbidities, including stroke, diabetes, sarcopenia, and cognitive disorders, modify epilepsy risk and prognosis. Complementary experimental and neurophysiological studies further elucidate how inflammation, ion channel modulation, and network instability contribute to seizure susceptibility.
Ongoing efforts integrate metabolic biomarkers, neurophysiological signatures, and real-world clinical data to refine epilepsy phenotyping. Future directions emphasize precision-medicine approaches that incorporate comorbidity burden, metabolic state, and network dynamics, with the goal of identifying modifiable targets and improving long-term outcomes in epilepsy.

Executive Summary：
Dr. Mei-Yun Cheng graduated from College of Medicine, Chung Shan Medical University in 2003, and received her neurological residency training in Chang Gung Memorial Hospital. She got her doctorate degree in the Institute of Molecular Medicine from the School of Life Sciences, National Tsing Hua University in 2017.
Dr. Cheng is an assistant professor in Chang Gung University. Her main academic interests include treatment of epilepsy, neuroimmunology (autoimmune encephalitis, multiple sclerosis) and spinal cord infarction. She is now the director of Taiwan Epilepsy Society (TES), Taiwan Neuroimmunology Medical Society (TNMS), and Taiwan Epilepsy Association.

Lecture Abstract：
Neuroinflammation is increasingly recognized as a core driver of seizures and epileptogenesis, not merely a downstream consequence of ictal activity. This presentation synthesizes current evidence linking immune activation to epilepsy across three interconnected domains. First, we review inflammatory cascades triggered by glial activation (microglia and astrocytes) and the release of key cytokines, including IL 1β and TNF α, which modulate voltage-gated ion channels and glutamatergic signaling, lower seizure threshold, and contribute to a self-perpetuating“vicious cycle”of seizures and inflammation. Furthermore, blood–brain barrier (BBB) disruption enables peripheral leukocyte infiltration and amplifies local immune signaling, promoting disease progression and drug resistance. Second, we focus on autoimmune epilepsies, highlighting antibody-mediated encephalitis: seizures associated with cell-surface antibodies (e.g., LGI1, NMDAR, GABA receptors) often respond favorably to immunotherapy, whereas disorders targeting intracellular antigens (e.g., GAD65, onconeural antibodies) are typically less responsive. Mechanistically, we contrast direct synaptic dysfunction (e.g., receptor internalization) with inflammation-driven cytotoxicity, and discuss how NMDAR antibodies can paradoxically promote network hyperexcitability via synaptic remodeling. Third, we address NORSE/FIRES as innate immunity–driven syndromes characterized by cytokine storm, where early immunotherapy, ketogenic diet, and emerging agents are being evaluated. By bridging immunology and epileptogenesis, we aim to identify precision medicine strategies to improve patient outcomes.

Executive Summary：
Dr. Chien-Chen Chou currently serves as an Attending Physician in the Epilepsy Section at Taipei Veterans General Hospital and as an Assistant Professor at National Yang Ming Chiao Tung University. His clinical expertise focuses on epilepsy, with a particular specialization in presurgical evaluation, electroencephalography (EEG), stereo-EEG (SEEG), and brain mapping.

Dr. Chou completed his epilepsy fellowship at the Grande Ospedale Metropolitano Niguarda in Milan, Italy. His contributions to the field have been recognized with multiple Epilepsy Research Awards and Medical Innovation Awards.

Dedicated to academic service and the advancement of neurological care, Dr. Chou currently serves as a Director of the Taiwan Epilepsy Society. He previously held the positions of Secretary General of the Taiwan Epilepsy Society and Deputy Secretary-General of the Taiwan Neurological Society.

Lecture Abstract：
Neuroimaging has evolved from a purely diagnostic tool into an indispensable pillar of modern epilepsy management, particularly for drug-resistant patients undergoing presurgical evaluation. This lecture provides a comprehensive update on the clinical utility of structural and functional magnetic resonance imaging (MRI/fMRI).

We will first address high-resolution structural MRI, the cornerstone for identifying epileptogenic substrates. The discussion will highlight optimized protocols for detecting subtle lesions, such as focal cortical dysplasia (FCD), and the application of advanced post-processing techniques in patients previously deemed "MRI-negative."

Subsequently, the role of functional MRI will be examined. Task-based fMRI has largely superseded the invasive Wada test for the lateralization and localization of eloquent cortices, including language and motor functions, which is crucial for surgical risk stratification. Furthermore, we will explore the emerging utility of resting-state fMRI (rs-fMRI). By analyzing intrinsic functional connectivity, rs-fMRI offers unique insights into epileptic networks, aiding in the localization of the seizure onset zone when structural findings are indeterminate.

Finally, the lecture will synthesize how integrating anatomical and functional data facilitates a multimodal approach. This integration is vital for formulating precise hypotheses for stereo-EEG (SEEG) implantation or resective surgery, ultimately aiming to maximize seizure-free outcomes while preserving neurological function.