會議議程

Executive Summary：
Dr. Yi-Jen Wu is a neurologist specializing in epilepsy. Her research focused on the neurophysiological mechanisms underlying how electrical stimulations affect brain functions, and the therapeutic potential of neuromodulations to treat brain disorders with aberrant hyperexcitability and circuitry such as seizure/epilepsy and cognitive disorders. Her work involves the neurophysiological mechanisms of neuromodulation techniques including transcranial direct current stimulation (tDCS), vagus nerve stimulation (VNS), focused ultrasound (FUS), and deep brain stimulation (DBS).
Her work regarding tDCS, VNS, and FUS has been published in leading journals such as the Journal of Physiology, Brain Stimulation, Ultrasonics Sonochemistry, Journal of Neuroscience, and Neuropharmacology. She also holds a patent for epileptic spike detection and has contributed as an author to Taiwan’s foundational textbook on non-invasive brain stimulation.
Dr. Wu is actively involved in academic societies, currently serving as Secretary-General and a board member of the Taiwan Society of Clinical Neurophysiology, as well as on the committees of the Taiwan Neurological Society and the Taiwan Epilepsy Society. Her work exemplifies the integration of clinical neurology and translational neuroscience, advancing therapeutic strategies through neuromodulation.

Lecture Abstract：
Effective treatment of neurological disorders is often limited by the blood brain barrier (BBB), which restricts the delivery of many therapeutic agents to the central nervous system. Achieving precise spatial targeting of drug delivery within the brain remains another critical unmet challenge. Focused ultrasound (FUS), when combined with intravenously administered microbubbles, has emerged as a promising noninvasive approach to transiently and reversibly increase BBB permeability and enhance regional drug delivery. Through ultrasound-induced microbubble oscillation, localized mechanical effects can temporarily open tight junctions within the cerebral vasculature, enabling targeted delivery of therapeutic molecules to specific brain regions.
Using this technique, recent advances have demonstrated the feasibility of delivering a wide range of therapeutics, including chemotherapeutic agents, antibodies, neurotrophic factors, and nanoparticle-based drugs. In particular, drug-loaded microbubbles provide an additional strategy for site-specific drug release, further improving targeting precision while minimizing systemic exposure. Preclinical studies and early clinical trials suggest potential applications in several neurological conditions, including brain tumors, Alzheimer’s disease, Parkinson’s disease, epilepsy, and stroke.
This presentation will review the mechanisms underlying ultrasound-mediated BBB modulation, emerging strategies utilizing drug-loaded microbubbles, and recent translational progress toward clinical implementation of ultrasound-enabled targeted drug delivery in neurological therapeutics.

Executive Summary：
陳睿正醫師為倫敦大學神經醫學博士，曾赴史丹佛及英國國家神經醫學中心進修，專精神經退化疾病創新治療。現任台灣臨床神經生理學會理事長，擁有20年經顱磁刺激（TMS）研究與教學經驗，執行超過2萬人次腦磁波治療。主治領域包括帕金森神波刀、中風磁刺激、失智症新藥與肉毒桿菌治療，並多次受邀於國際學術會議演講。致力推動腦刺激技術與臨床應用，期望造福更多病患。

Lecture Abstract：
Ultrasound is emerging as an important tool in treating movement disorders, and we applied a dual-target MR-guided Focused Ultrasound (dtMRgFUS) approach for Parkinson’s disease (PD). This method sequentially targets the ventral intermediate nucleus (VIM) and the pallidothalamic tract (PTT) to overcome the limitations of single-target interventions. Our investigation examined the immediate therapeutic effects of adding PTT lesioning after VIM ablation.

Executive Summary：
Dr. Hsueh-Wen Hsueh started his residency in Department of Neurology in National Taiwan University Hospital and accomplished the training in 2017. He became the attending physician in Department of Neurology of National Taiwan University Hospital at the same year. His research interest is imaging and histopathological studies in different neuromuscular disorders. He established the neuromuscular ultrasound and MRI with several published articles in the Department of Neurology of National Taiwan University Hospital. He also engaged in several clinical trials of neuromuscular disorders.

Lecture Abstract：
Ultrasound has become an essential extension of electrodiagnostic studies in the evaluation of neuromuscular diseases (NMDs), particularly for disorders involving the peripheral nerves. This lecture emphasizes the clinical role of nerve ultrasound in refining localization, clarifying etiology, and enhancing diagnostic confidence, using a case-based learning framework derived from routine neurological practice .
Conventional diagnostic workflows for NMDs rely on history taking, neurological examination, and nerve conduction studies/electromyography (NCS/EMG). Nerve ultrasound fundamentally complements this process by providing real-time anatomical information that is not available from electrophysiology alone. In mononeuropathies, ultrasound allows precise identification of focal nerve enlargement, entrapment sites, or structural abnormalities, and enables direct comparison with the contralateral side—particularly valuable when NCS/EMG findings are inconclusive. In polyneuropathies, nerve ultrasound shifts the diagnostic focus toward recognizing disease-specific patterns of nerve involvement across multiple sites, supporting disease classification and longitudinal assessment.
The lecture is structured around case-based learning, illustrating how nerve ultrasound alters clinical reasoning and diagnostic decisions in representative scenarios, including hereditary neuropathies, immune-mediated neuropathies, and atypical entrapment syndromes. Selected cases also demonstrate the added value of ultrahigh-frequency ultrasound in visualizing small or superficial nerves.
In summary, nerve ultrasound is a non-invasive, cost-effective, and anatomically intuitive modality that integrates seamlessly with electrodiagnostic studies. When applied through a case-based approach, it serves as a powerful tool for both clinical practice and neuromuscular education